Chemical Cascading Between Polymersomal Nanoreactor Populations

Harnessing interactions of functional nano-compartments to generate larger particle assemblies allows studying diverse biological behaviors based on their population states and can lead the development smart materials. Herein, thiol-functionalized polymersome nanoreactors are utilized as responsive organelle-like nano-compartments—with inherent capacity associate into aggregates in response change redox state environment—to study kinetics cascade reactions explore functions collective under different states. Two nanoreactor populations, glucose oxidase- horseradish peroxidase-loaded polymersomes, prepared, results cascading upon addition investigated. The resorufin production associated polymersomes non-associated populations compared, observing a decreased rate association. For faster chemical is found when two types concerted step, compared sequential competing agents such catalase impacts communication between whereas an effect less pronounced for ones. Altogether, showcase impact associations enzymatic nanoreactors.